Combinations ; - see below
1. Metronidazole / Diloxanide /Simethicone
2. Metronidazole / Diloxanide furoate
3. Metronidazole / Miconazole pessaries
4. Metronidazole/ Diloxanide furoate / Dicyclomine
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Unizole | Pharmaceuticals Manufacturing Co. k Ltd. | Pharmaceutical Manufacturing Co.(K) Ltd | 200mg | 60ml | Suspension | per 5ML | KES POR |
| Zagole | GlaxoSmithkline | GlaxoSmithKline | 200mg | 60ml | Suspension | per 5ML | KES 112.00 |
| Zagole | GlaxoSmithkline | GlaxoSmithKline | 200mg | 100ml | Suspension | per 5ML | KES 164.00 |
| Amebazole | Sphinx Pharmaceuticals Ltd | Omaera Pharmaceuticals Ltd | 200mg/5ml | 60ml | Suspension | per 5ML | KES 23.00 |
| Amebazole | Sphinx Pharmaceuticals Ltd | Omaera Pharmaceuticals Ltd | 200mg/5ml | 100ml | Suspension | per 5ML | KES 34.00 |
| Amebazole | Sphinx Pharmaceuticals Ltd | Omaera Pharmaceuticals Ltd | 200mg | 1000 | Tablet | per tablet | KES 600.00 |
| Amebazole | Sphinx Pharmaceuticals Ltd | Omaera Pharmaceuticals Ltd | 400mg | 500 | Tablet | per tablet | KES 580.00 |
| Amebazole | Sphinx Pharmaceuticals Ltd | Omaera Pharmaceuticals Ltd | 200mg | 1000 | Tablet | per tablet | KES 380.00 |
| Amebazole | Sphinx Pharmaceuticals Ltd | Omaera Pharmaceuticals Ltd | 400mg | 500 | Tablet | per tablet | KES 380.00 |
| Amizole | Biopharma Laboratories Ltd. | Maxim Pharmaceuticals Ltd | 200mg/5ml | 60ml | Suspension | per 5ML | KES 25.00 |
| Amizole | Biopharma Laboratories Ltd. | Maxim Pharmaceuticals Ltd | 200mg/5ml | 100ml | Suspension | per 5ML | KES 35.00 |
| Amizole | Biopharma Laboratories Ltd. | Maxim Pharmaceuticals Ltd | 200mg | 1000 | Tablet | per tablet | KES 390.00 |
| Biozole | Sanofi Aventis | Surgipharm Ltd | 5mg | 100ml | Injection | per vial | KES 150.60 |
| Eflaron | Dawa Limited | Dawa Limited | 200mg | 100 | Tablet | per tablet | KES 65.00 |
| Eflaron | Dawa Limited | Dawa Limited | 200mg | 30 | Tablet | per tablet | KES 90.00 |
| Eflaron | Dawa Limited | Dawa Limited | 200mg | 1000 | Tablet | per tablet | KES 400.00 |
| Eflaron | Dawa Limited | Dawa Limited | 200mg | 1000 | Tablet | per tablet | KES 560.00 |
| Eflaron | Dawa Limited | Dawa Limited | 400mg | 500 | Tablet | per tablet | KES 400.00 |
| Eflaron | Dawa Limited | Dawa Limited | 200mg/5ml | 60ml | Suspension | per 5ML | KES 23.00 |
| Eflaron | Dawa Limited | Dawa Limited | 200mg/5ml | 100ml | Suspension | per 5ML | KES 35.00 |
| Elogyl | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 200mg | 100 | Tablet | per tablet | KES 60.00 |
| Elogyl | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 200mg | 1000 | Tablet | per tablet | KES 495.00 |
| Elogyl | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 400mg | 100 | Tablet | per tablet | KES 115.00 |
| Elogyl | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 400mg | 500 | Tablet | per tablet | KES 495.00 |
| Elogyl | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 400mg | 1000 | Tablet | per tablet | KES 650.00 |
| Elogyl | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 200mg/5ml | 60ml | Suspension | per 5ML | KES 30.00 |
| Elogyl | Elys Chemicals Industries Ltd. | Elys Chemical Industries Ltd. | 200mg/5ml | 100ml | Suspension | per 5ML | KES 40.00 |
| Filmet | Beximco Pharma | Madawa Pharmaceuticals Ltd. | 200mg/5ml | 60ml | Suspension | per 5ML | KES 124.00 |
| Flagimed | Medivet Products Ltd | Medivet Products Ltd. | 200mg | 60ml | Suspension | per 5ML | KES POR |
| Flagyl | Sanofi Aventis | Surgipharm Ltd | 200mg | 250 | Tablet | per tablet | KES 592.00 |
| Flagyl | Sanofi Aventis | Surgipharm Ltd | 400mg | 100 | Tablet | per tablet | KES 488.00 |
| Flagyl | Sanofi Aventis | Surgipharm Ltd | 200mg/5ml | 100ml | Suspension | per 5ML | KES 429.00 |
| Flagyl | Sanofi Aventis | Surgipharm Ltd | 5mg/ml | 100ml | Infusion | KES 192.00 | |
| Flagyl viaflex | Sanofi Aventis | Surgipharm Ltd | 100ml | 100ml | infusion | per ml | KES 195.00 |
| Medzol | Syner-Medica (K) Ltd | Syner-Medica (K) Ltd | 400mg | 30 | Tablet | per tablet | KES 100.00 |
| Medzol | Syner-Medica (K) Ltd | Syner-Medica (K) Ltd | 400mg | 500 | Tablet | per tablet | KES 380.00 |
| Medzol | Syner-Medica (K) Ltd | Syner-Medica (K) Ltd | 400mg | 500 | Tablet | per tablet | KES 350.00 |
| Megyl | Regal Pharmaceuticals | Regal Pharmaceuticals Limited | 200mg/5ml | 60ml | Suspension | per 5ML | KES 50.00 |
| Megyl | Regal Pharmaceuticals | Regal Pharmaceuticals Limited | 200mg/5ml | 100ml | Suspension | per 5ML | KES 60.00 |
| Megyl | Regal Pharmaceuticals | Regal Pharmaceuticals Limited | 200mg | 100 | Tablet | per tablet | KES 87.00 |
| Megyl | Regal Pharmaceuticals | Regal Pharmaceuticals Limited | 200mg | 1000 | Tablet | per tablet | KES 499.00 |
| Megyl | Regal Pharmaceuticals | Regal Pharmaceuticals Limited | 400mg | 1000 | Tablet | per tablet | KES 822.00 |
| Metris | Claris Lifesciences Ltd. | Saicare Enterprises Ltd. | 0.5% | 100ml | Injection | per vial | KES 30.00 |
| Metrogyl | Unique Pharmaceuticals Laboratories | Pharma Specialities Ltd. | 5mg/ml | 100ml | infusion | per ml | KES 25.00 |
| Metronidazole | Marck Biosciences Ltd | Surgilinks Ltd. | 5mg/ml | 100ml | Injection | per vial | KES 25.00 |
| Metronyl | Macs Pharmaceuticals | Mac?s Pharmaceuticals Ltd | 2000mg | 1000 | Tablet | per tablet | KES 456.00 |
| Metronyl | Macs Pharmaceuticals | Mac?s Pharmaceuticals Ltd | 200mg/5ml | 60ml | Suspension | per 5ML | KES 26.00 |
| Metrozol | Cosmos Limited. | Cosmos Limited | 200mg | 100 | Tablet | per tablet | KES 150.00 |
| Metrozol | Cosmos Limited. | Cosmos Limited | 400mg | 100 | Tablet | per tablet | KES 300.00 |
| Metrozol | Cosmos Limited. | Cosmos Limited | 200mg/5ml | 60ml | Suspension | per 5ML | KES 60.00 |
| Metrozol | Cosmos Limited. | Cosmos Limited | 200mg/5ml | 100ml | Suspension | per 5ML | KES 105.00 |
| Nelzole | Universal Pharmaceuticals Ltd. | Saicare Enterprises Ltd. | 200mg | 1000 | Tablet | per tablet | KES 1,200.00 |
| Nelzole | Universal Pharmaceuticals Ltd. | Saicare Enterprises Ltd. | 400mg | 500 | Tablet | per tablet | KES 1,200.00 |
| Nelzole | Universal Pharmaceuticals Ltd. | Saicare Enterprises Ltd. | 200mg/5ml | 60ml | Suspension | per 5ML | KES 43.00 |
| Nelzole | Universal Pharmaceuticals Ltd. | Saicare Enterprises Ltd. | 200mg/5ml | 100ml | Suspension | per 5ML | KES 47.00 |
| Nidagyl | OSS-Chemie k Ltd | Njimia Pharmaceuticals Ltd. | 200mg/5ml | 60ml | Suspension | per 5ML | KES 24.00 |
| Nidagyl | OSS-Chemie k Ltd | Njimia Pharmaceuticals Ltd. | 200mg/5ml | 100ml | Suspension | per 5ML | KES 34.00 |
| Trichogyl | Tablets India Ltd. | Harley's Limited | 0.5g | 100ml | Injection | per vial | KES 29.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 200mg/5ml | 60ml | Suspension | per 5ML | KES 25.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 200mg/5ml | 100ml | Suspension | per 5ML | KES 40.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 200mg | 1000 | Tablet | per tablet | KES 550.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 200mg | 1000 | Tablet | per tablet | KES 450.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 400mg | 500 | Tablet | per tablet | KES 450.00 |
| Wescogyl | West Coast Pharmaceuticals Works Ltd | Ray Pharmaceuticals Ltd | 200mg | 1000 | Tablet | per tablet | KES 400.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 200mg/5ml | 60ml | Suspension | per 5ML | KES 25.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 200mg/5ml | 100ml | Suspension | per 5ML | KES 40.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 200mg | 1000 | Tablet | per tablet | KES 550.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 200mg | 1000 | Tablet | per tablet | KES 450.00 |
| Trogyl | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 400mg | 500 | Tablet | per tablet | KES 450.00 |
| Calzole | Concept (Africa) Limited | Concept (Africa) Limited | 200mg | 60ml | Suspension | per 5ML | KES 22.00 |
| Calzole | Concept (Africa) Limited | Concept (Africa) Limited | 200mg | 100ml | Suspension | per 5ML | KES 32.00 |
| Metronidazole More info | |
|---|---|
| Mode Of Action | Metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its which covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis |
| Drug Indication | Invasive intestinal amoebiasis, Giardiasis, Urogenital trichmoniasis, Acute dental infections. Surgical prophylaxis, leg ulcer and pressure sore, bacterial vaginosis, acute ulcerative gingivitis. |
| Precautions | Avoid alcohol, pseudomembranous colitis, concurrent antihypertensive therapy. |
| Contra-Indications | Pregnancy and lactation, blood dyscrasia, CNS disturbances. |
| Side Effects | GI discomfort, anorexia, metallic taste, dry mouth, headache, skin rash, vertigo, depression, insomnia, drowsiness, urethral discomfort, darkened urine, transient fall in BP, temporary leucopenia, bone marrow depression, transient epileptic seizure, furred tongue. |
| Dosage | Invasive intestinal amoebiasis: 800mg TID x 5/7. 3-7years; 200mg QID x 5/7. 7-10years; 200-400mg TID. Giardiasis: 2g daily 3/7. Children, 1-3years: 500mg daily, 3-7years; 600-800mg daily, 7-10years; 1g daily. Urogenital trichmoniasis: 200mg TID x 1/52 or 400mg BD x 1/52 or 800mg morning and 1.2g at night for 2 days or 2g stat. Children: 1-3years; 500mg TID 1/52, 3-7years; 100mg TID 1/52, 7-10years; 100mg TID 1/52. Acute dental infections: 400mg TID. Surgical prophylaxis, leg ulcer and pressure sore, bacterial vaginosis, acute ulcerative gingivitis. |
| Pregnancy Category | Category B2 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals are inadequate or lacking but available data show no evi-dence of an increased occurrence of foetal damage. Studies in animals are inadequate or lacking but available data show no evi-dence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Amoebics |
| 1. Metronidazole / Diloxanide /Simethicone | |
|---|---|
| Mode Of Action | Metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its which covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis |
| Drug Indication | Diloxanide furoate is active against the cystic form of amoeba. Hence the combination is effective in all forms of amoebiasis. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Amoebics |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Betrozole | Beta Healthcare International Ltd | Beta Healthcare International Ltd | 200mg/250mg | 30 | Tablet | per tablet | KES 180.00 |
| Betrozole | Beta Healthcare International Ltd | Beta Healthcare International Ltd | 200mg/250mg/25mg | 30 | Tablet | per tablet | KES 150.00 |
| Betrozole | Beta Healthcare International Ltd | Beta Healthcare International Ltd | 100mg/120mg/25mg/5ml | 60ml | Suspension | per 5ML | KES 95.00 |
| Betrozole | Beta Healthcare International Ltd | Beta Healthcare International Ltd | 100mg/120mg/25mg/5ml | 100ml | Suspension | per 5ML | KES 147.00 |
| Orogyl-DF | FDC. Ltd | Wessex Pharmaceuticals Limited | 200mg/250mg/25mg | 100 | Tablet | per tablet | KES 475.00 |
| Trogyl plus | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 100mg/125mg | 60ml | Suspension | per 5ML | KES 60.00 |
| Trogyl plus | Biodeal Laboratories Ltd. | Biodeal Laboratories Ltd. | 100mg/125mg | 100ml | Suspension | per 5ML | KES 85.00 |
| 2. Metronidazole / Diloxanide furoate | |
|---|---|
| Mode Of Action | Metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its which covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis |
| Drug Indication | Diloxanide furoate is active against the cystic form of amoeba. Hence the combination is effective in all forms of amoebiasis. |
| Precautions | |
| Contra-Indications | |
| Side Effects | |
| Dosage | tabs TID x 5/7 (10/7 in refractory cases). Children 5-12 years; 1/2 tab or 10mL TIDx5/7.Children below 5 years: 5mL TIDx5/7. |
| Pregnancy Category | Category B2 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals are inadequate or lacking but available data show no evi-dence of an increased occurrence of foetal damage. Studies in animals are inadequate or lacking but available data show no evi-dence of an increased occurrence of foetal damage. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Amoebics |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Benagyl DF | Benmed Pharmaceuticals Ltd | Benmed Pharmaceuticals Ltd | 200mg/250mg | 30 | Tablet | per tablet | KES 108.00 |
| Benagyl DF | Benmed Pharmaceuticals Ltd | Benmed Pharmaceuticals Ltd | 100mg/125mg | 60ml | Suspension | per 5ML | KES 80.00 |
| Benagyl DF | Benmed Pharmaceuticals Ltd | Benmed Pharmaceuticals Ltd | 100mg/125mg | 100ml | Suspension | per 5ML | KES 108.00 |
| Difil-M | Fourts PVT Ltd. | Sai Pharmaceuticals Ltd. | 400mg/500mg | 15 | Tablet | per tablet | KES 117.00 |
| Diracip M | Cipla Ltd. | Surgipharm Ltd | 250mg/200mg | 30 | Tablet | per tablet | KES 155.00 |
| Diracip M | Cipla Ltd. | Surgipharm Ltd | 400mg/500mg | 15 | Tablet | per tablet | KES 155.00 |
| Diracip M | Cipla Ltd. | Surgipharm Ltd | 100mg/125mg | 1 | Suspension | per 5ML | KES 165.00 |
| Dyrade-M | Cipla Ltd. | Surgipharm Ltd | 200mg/250mg | 30 | Tablet | per tablet | KES 124.00 |
| Dyrade-M | Cipla Ltd. | Surgipharm Ltd | 400mg/500mg | 15 | Tablet | per tablet | KES 124.00 |
| Dyrade-M | Cipla Ltd. | Surgipharm Ltd | 100mg/125mg/1ml | 100ml | Suspension | per 5ML | KES 143.00 |
| Eflaron Plus | Dawa Limited | Dawa Limited | 200mg/250mg | 30 | Tablet | per tablet | KES 90.00 |
| Eflaron Plus | Dawa Limited | Dawa Limited | 200mg/250mg | 100ml | Suspension | per 5ML | KES 85.00 |
| Entamizole | Abbott Laboratories | Surgipharm Ltd | 200mg/250mg | 30 | Tablet | per tablet | KES 404.00 |
| Entamizole | Abbott Laboratories | Surgipharm Ltd | 200mg/250mg | 15 | Tablet | per tablet | KES 404.00 |
| Entamizole | Abbott Laboratories | Surgipharm Ltd | 100mg/125mg | 100ml | Suspension | per 5ML | KES 338.00 |
| Furamebe Forte | Sedico Pharmaceuticals | Three Pyramids Company Limited | 200mg/250mg | 20 | Tablet | per tablet | KES 135.00 |
| Betrozole | Beta Healthcare International Ltd | Beta Healthcare International Ltd | 200mg/250mg/25mg | 30 | Tablet | per tablet | KES 150.00 |
| Betrozole | Beta Healthcare International Ltd | Beta Healthcare International Ltd | 100mg/120mg/25mg | 60ml | Suspension | per 5ML | KES 95.00 |
| Betrozole | Beta Healthcare International Ltd | Beta Healthcare International Ltd | 100mg/120mg/25mg | 100ml | Suspension | per 5ML | KES 147.00 |
| Furazol | E.I.P.C.O. | Zadchem Pharmacy Ltd. | 200mg/250mg | 30 | Tablet | per tablet | KES 230.00 |
| Furazol | E.I.P.C.O. | Zadchem Pharmacy Ltd. | 100mg/125mg | 100ml | Suspension | per 5ML | KES 230.00 |
| 3. Metronidazole / Miconazole pessaries | |
|---|---|
| Mode Of Action | Nystatin has both fungicidal and fungistatic properties. It binds to sterols in the cell membrane of the fungus with a resultant change in membrane permeability, allowing leakage of intracellular components and causing cell death. |
| Drug Indication | Mixed vaginal infections |
| Dosage | One pessary inserted high into vagina at night for 7 days. Resistant cases, 14 days |
| Drug Category | DRUGS ACTING ON GENITO-URINARY SYSTEM |
| Drug Sub-Category | Drugs for vaginal conditions |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Neo-penotran forte | Bayer Schering Pharma | Bayer East Africa Ltd. | 750mg/250mg | 7 | Pessaries | KES 1,054.36 |
| 4. Metronidazole/ Diloxanide furoate / Dicyclomine | |
|---|---|
| Mode Of Action | Metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its which covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis |
| Drug Indication | Diloxanide furoate is active against the cystic form of amoeba. Hence the combination is effective in all forms of amoebiasis. |
| Drug Category | DRUGS ACTING ON INFECTIONS |
| Drug Sub-Category | Anti-Amoebics |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Tridazole | OSS-Chemie k Ltd | Njimia Pharmaceuticals Ltd. | 100mg/125mg/5mg | 60ml | Suspension | per 5ML | KES 52.00 |
| Tridazole | OSS-Chemie k Ltd | Njimia Pharmaceuticals Ltd. | 100mg/125mg/5mg | 100ml | Suspension | per 5ML | KES 75.00 |
| Contamizole | Concept (Africa) Limited | Concept (Africa) Limited | 100mg/125mg/5mg | 100ml | Suspension | per 5ML | KES 70.00 |